applications of autodisplay system for recombinant protein expression on the bacterial cell surface

protein secretory systems are found in all living organisms including gram negative bacteria, and eukaryotic cell’s organelles that are derived from these bacteria. unlike all other living organisms, gram negative bacteria have different protein secretory systems. at least there are four different independent secretory systems, which are responsible to transport the secreted proteins to the milieu or insert them into the bacterial cell surface. comprising these systems in bacteria suggests that, beside the biogenic, mechanistic and evolutionary similarities, each acting independently. to display a protein or peptide with a distinct function at the surface of a living bacterial cell, is a challenging exercise with constantly increasing impact in many areas of biochemistry and biotechnology. autodisplay system is developed based on autotransporters. this article introduces autodisplay protein expression based on autotransporters, on the bacterial cell surface, and their different potential applications and also in vaccine production.